Now you can use the DMC sofware in Mac OSX! A experimental Homebrew repository is now available, containing gfal2 and its required dependencies.
gfal2-python and gfal2-util are not distributed via Homebrew (yet), but can be installed using pip. Have a look at the Readme.md file to see how to get the software installed.
The gfal2 Python bindings are now available in PyPI. So all you need to do now in your virtual environment is just
pip install "gfal2-python"
And you are good to go. Mind that the gfal2 development libraries must be installed, among other dependencies. Check the entry in PyPI to see what is required.